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  • Title: Isoprostanes quickly normalize after quitting cigarette smoking in healthy adults.
    Author: Oguogho A, Lupattelli G, Palumbo B, Sinzinger H.
    Journal: Vasa; 2000 May; 29(2):103-5. PubMed ID: 10901086.
    Abstract:
    BACKGROUND: Isoprostanes and in particular 8-epi-PGF2 alpha have been claimed as a useful measure for invivo oxidation injury. While smokers show elevated 8-epi-PGF2 alpha the behaviour during quitting smoking is unknown. METHODS AND RESULTS: We determined 8-epi-PGF2 alpha in 7 healthy adults ready to quit smoking in plasma, serum and urine by means of an enzyme immunoassay after extraction and purification before quitting smoking and during a follow-up period of 4 weeks. After quitting smoking, 8-epi-PGF2 alpha shows a rapid decline within a few days almost completely normalizing within 4 weeks. CONCLUSION: The cigarette-smoking associated invivo oxidation injury almost completely disappears within 4 weeks of quitting smoking.
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