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  • Title: Selectivity of the spatial learning deficit after lesions of the mammillary region in rats.
    Author: Sziklas V, Petrides M.
    Journal: Hippocampus; 2000; 10(3):325-8. PubMed ID: 10902901.
    Abstract:
    Rats with lesions of the mammillary region (MB-R) or a control group (C) were trained on a visual-spatial conditional associative learning task in which they had to learn to go to one of two locations depending on the particular visual cue presented on each trial; the rats approached the cues from different directions. The animals were subsequently tested on a spatial working memory task, the eight-arm radial maze. Rats with damage to the MB-R were able to acquire the conditional associative task at a rate comparable to that of the C animals. By contrast, lesions of the MB-R led to a severe impairment on the radial maze. The present finding of a dissociation between the effects of MB-R lesions on two different classes of behavior suggest that the spatial learning deficit following damage of this region may be specific to remembering one or more places over a given time but not the ability to form associations between visual and spatial stimuli.
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