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  • Title: Maternal care, hippocampal synaptogenesis and cognitive development in rats.
    Author: Liu D, Diorio J, Day JC, Francis DD, Meaney MJ.
    Journal: Nat Neurosci; 2000 Aug; 3(8):799-806. PubMed ID: 10903573.
    Abstract:
    We report that variations in maternal care in the rat promote hippocampal synaptogenesis and spatial learning and memory through systems known to mediate experience-dependent neural development. Thus, the offspring of mothers that show high levels of pup licking and grooming and arched-back nursing showed increased expression of NMDA receptor subunit and brain-derived neurotrophic factor (BDNF) mRNA, increased cholinergic innervation of the hippocampus and enhanced spatial learning and memory. A cross-fostering study provided evidence for a direct relationship between maternal behavior and hippocampal development, although not all neonates were equally sensitive to variations in maternal care.
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