These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Plasma and tissue concentrations of beta-carotene and vitamin A in rats fed beta-carotene in various fats of plant and animal origin.
    Author: Schweigert FJ, Baumane A, Buchholz I, Schoon HA.
    Journal: J Environ Pathol Toxicol Oncol; 2000; 19(1-2):87-93. PubMed ID: 10905513.
    Abstract:
    We investigated the effects of various types of dietary fat of plant and animal origin on beta-carotene absorption and tissue accumulation in rats. Rats were fed 1 mL of butter fat, lard, tallow, sunflower, arachidonic, soya, olive, or linseed oil containing 175 mg beta-carotene/mL fat by gavage, twice a week for 4 weeks. The beta-carotene and vitamin A levels in plasma and tissues were determined by rp-HPLC. The highest levels of absorbed beta-carotene were observed in the liver of animals fed olive and arachidonic oil (p < 0.001), and in the lungs of animals fed sunflower oil. Histomorphological studies showed that the observed highly variable accumulation of beta-carotene in lung tissue was most probably due to an endogenously caused lipid pneumonia. No beta-carotene was observed in blood plasma, kidney, and spleen in any group. Plasma vitamin A levels (retinol) were increased with tallow, olive, and arachidonic oil (p < 0.05). The most obvious influence was found for vitamin A in the spleen. Levels in rats fed tallow (p < 0.05), butter, or lard (p < 0.001) were higher than in controls. The lowest vitamin A levels were found in rats fed fat of plant origin. Our results suggest that the type of dietary fat can modulate the absorption of beta-carotene as well as the distribution of vitamin A in plasma and selected tissues.
    [Abstract] [Full Text] [Related] [New Search]