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  • Title: Serum Lp(a) lipoprotein levels in patients with atherosclerotic occlusive disease of the lower extremities.
    Author: Dionyssiou-Asteriou A, Papastamatiou M, Vatalas I, Bastounis E.
    Journal: Eur J Vasc Endovasc Surg; 2000 Jul; 20(1):57-60. PubMed ID: 10906299.
    Abstract:
    OBJECTIVE: To evaluate the association between Lp(a) lipoprotein levels, other serum lipids and the presence of lower limb atherosclerotic occlusive disease. MATERIALS AND METHODS: Angiographic findings in 36 patients were related to serum Lp(a). Total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol and Lp(a) levels were compared with those of 73 age- and sex-matched healthy controls. RESULTS: Atheromatous lesions were localised in the femoropopliteal ( approximately 60%) and aortoiliac ( approximately 40%) segments. The number of stenosed arteries was > or =2 and the range of stenosis severity was between 40% and 100%. There was a significant increase in serum Lp(a) (p= 0.000001) and a decrease in serum HDL (p= 0.000009) levels in patients compared to controls. No difference was observed in total cholesterol, LDL-cholesterol or triglyceride. However, the ratio of total cholesterol/HDL-cholesterol was significantly higher (p= 0.005) in patients. CONCLUSION: A dyslipidaemic serum profile, characterised by increased Lp(a) levels and decreased HDL-cholesterol levels, is associated with atherosclerotic occlusive disease of the lower extremities.
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