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  • Title: Benign, borderline, and malignant endometrioid neoplasia arising in endometriosis in association with tamoxifen therapy.
    Author: McCluggage WG, Bryson C, Lamki H, Boyle DD.
    Journal: Int J Gynecol Pathol; 2000 Jul; 19(3):276-9. PubMed ID: 10907178.
    Abstract:
    Tamoxifen therapy may result in a variety of endometrial proliferative lesions, including adenocarcinoma, and as recently suggested, proliferative changes within endometriosis. This report describes an endometrioid adenocarcinoma arising in ovarian endometriosis in a patient taking tamoxifen. There were also foci of benign and borderline endometrioid adenofibroma in the same ovary and a synchronous endometrioid endometrial adenocarcinoma in the uterus. The spectrum of benign, borderline, and malignant endometrioid neoplasia arising within endometriosis suggests that tamoxifen, as a result of its estrogenic effects, may cause proliferative and, in rare instances, malignant changes in endometriosis.
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