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  • Title: IB-96212, a novel cytotoxic macrolide produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation and biological activities.
    Author: Fernández-Chimeno RI, Cañedo L, Espliego F, Grávalos D, De La Calle F, Fernández-Puentes JL, Romero F.
    Journal: J Antibiot (Tokyo); 2000 May; 53(5):474-8. PubMed ID: 10908110.
    Abstract:
    A novel bioactive macrolide, IB-96212 has been isolated from the fermentation broth of a marine actinomycete, L-25-ES25-008. The strain belongs to the genus Micromonospora. The macrolide showed a very strong cytotoxic activity against P-388, and lower but significant activity against A-549, HT-29, and MEL-28 cell lines. We describe the isolation, taxonomy and fermentation of the producing strain as well as the isolation of IB-96212.
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