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  • Title: The galactose-binding and mannose-binding jacalin-related lectins are located in different sub-cellular compartments.
    Author: Peumans WJ, Hause B, Van Damme EJ.
    Journal: FEBS Lett; 2000 Jul 21; 477(3):186-92. PubMed ID: 10908718.
    Abstract:
    A galactose-specific and a mannose-specific lectin of the family of the jacalin-related lectins have been localized by immunofluorescence microscopy. The present localization studies provide for the first time unambiguous evidence for the cytoplasmic location of the mannose-specific jacalin-related lectin from rhizomes of Calystegia sepium, which definitely differs from the vacuolar location of the galactose-specific jacalin from Artocarpus integrifolia. These observations support the hypothesis that the galactose-specific jacalin-related lectins evolved from their mannose-specific homologues through the acquisition of vacuolar targeting sequences.
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