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  • Title: Neonatal intestinal perforation caused by congenital defect of the small intestinal musculature: report of one case.
    Author: Huang PC, Yau KI, Wu MZ, Huang SF.
    Journal: Acta Paediatr Taiwan; 1999; 40(4):271-3. PubMed ID: 10910628.
    Abstract:
    Congenital defect of the small intestinal musculature is a rare cause of neonatal spontaneous intestinal obstruction or perforation. Its etiology and pathogenesis are still controversial. A male infant presented with intestinal obstruction at two days of age and rapidly progressed to perforation and septic shock. He died at seven days of age. Autopsy finding revealed a perforation hole at twenty-five cm proximal to ileocecal valve. Histology examination demonstrates multifocal deficiency of the inner circular muscle layer three cm around the perforation site. The clinical and histological characteristics are reviewed and discussed. We propose that the muscle defect of small intestine, especially ileum, is secondary to ischemic injury rather than an embryological malformation.
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