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  • Title: Studies on the mechanism of somatostatin action on insulin release in man. I. Effect of blockade of alpha-adrenergic receptors.
    Author: Efendić S, Luft R.
    Journal: Acta Endocrinol (Copenh); 1975 Mar; 78(3):516-23. PubMed ID: 1091119.
    Abstract:
    The present studies have demonstrated that the growth hormone releaseinhibiting factor of the hypothalamus, somatostatin, exerts a prominent inhibiting action on glucose induced insulin release in man. This inhibition of insulin release could not be reversed by infusion of the alpha-adrenergic blocking agent, phentolamine. Our findings therefore suggest that the inhibiting effect of somatostatin on glucose induced insulin release is not mediated by the alpha-adrenergic receptors.
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