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  • Title: [Palliation of bone pain in metastatic prostate carcinoma. Value of radionuclide therapy with rhenium 186 HEDP].
    Author: Klutmann S, Bohuslavizki KH.
    Journal: MMW Fortschr Med; 1999 Nov 04; 141(44):38-9. PubMed ID: 10912142.
    Abstract:
    Pain caused by bone metastases from carcinoma of the prostate are treated in particular by non-steroidal anti-inflammatory drugs and opioid-containing analgesics. In case of painful multilocular metastases, the use of osteotropic radionuclides which selectively irradiate the bone metastases while sparing healthy surrounding tissue offers an alternative. Owing to their favorable physical properties, rhenium-186 and samarium-153 are preferentially used. The rate of side effects--for the most part transient thrombocytopenia--is low, and the response rate is roughly 70 to 80% of the patients treated. Pain relief may last for between 1 and 6 months, with the option of multiple treatments. The prognosis of the disease is, however, not affected.
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