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  • Title: (131)I and thyroid-associated ophthalmopathy.
    Author: Rasmussen AK, Nygaard B, Feldt-Rasmussen U.
    Journal: Eur J Endocrinol; 2000 Aug; 143(2):155-60. PubMed ID: 10913933.
    Abstract:
    OBJECTIVE: Radioiodine ((131)I) used to obtain euthyroidism in thyrotoxic patients is suspected of having a worsening or provoking effect on thyroid-associated ophthalmopathy (TAO), an autoimmune disease closely related to Graves' disease. DESIGN: This review summarises the existing literature and describes risk factors influencing the course of TAO including thyroid function, cigarette smoking and treatment of Graves' hyperthyroidism (especially (131)I therapy). CONCLUSION: It is recommended that patients who may be at a greater risk of worsening ophthalmopathy are considered when choosing the modality of therapy of hyperthyroidism and also in deciding whether prophylactic systemic glucocorticoid treatment is indicated.
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