These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Selective blockade of muscarinic receptor subtypes in the brain stem reticular formation in rats: effects on anesthetic requirements.
    Author: Ishizawa Y.
    Journal: Brain Res; 2000 Aug 04; 873(1):124-6. PubMed ID: 10915817.
    Abstract:
    Muscarinic involvement in the modulation of general anesthesia was examined in the rat with a cannula implanted in the pontine reticular formation. Atropine microinjected into the reticular formation reversed the minimum alveolar concentration (MAC) reducing effect of carbachol on halothane anesthesia, but M(1) or M(3) antagonist had no effect. An M(2) antagonist reduced the MAC of halothane following saline and carbachol. The results suggest that any of the muscarinic receptor subtypes in this region do not independently mediate the cholinomimetic effect on halothane anesthesia.
    [Abstract] [Full Text] [Related] [New Search]