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  • Title: Oxime derivatives of erythromycin: inhibitors of Rous sarcoma virus reverse transcriptase activity and focus formation.
    Author: Panigraphy B, McCormick KJ, Stenback WA, Trentin JJ.
    Journal: J Gen Virol; 1975 Jan; 26(1):141-3. PubMed ID: 1091717.
    Abstract:
    Bovine adenovirus type 3 (BAV-3), strain WBR-1, quantitatively transforms hamster embryo carcass cells with a maximum efficiency of 4-7 X 10-4 p.f.u./focus-forming units (f.f.u). This frequency is signigicantly inhibited by the presence of 1-8 mM of Ca++. The transformed cells are highly tumourigenic in hamsters and possess T- and tumour-specific transplantation antigens. BAV-3 is one of the most oncogenic of the adenoviruses and an ideal model virus for the study of transformation.
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