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  • Title: Stimulatory effect of prostaglandin E2 on LH release in the rat: evidence for hypothalamic site of action.
    Author: Chobsieng P, Naor Z, Koch Y, Zor U, Lindner HR.
    Journal: Neuroendocrinology; 1975; 17(1):12-7. PubMed ID: 1091873.
    Abstract:
    The intravenous administration of prostaglandin E2 (PGE2; 100 mug/rat) to immature male and female rats increased the serum level of lutenizing hormone (LH). This effect was prevented by the prior administration of an antiserum to the hypothalamic gonadotropin-releasing hormone. LH release from rat pituitaries in vitro was not stimulated by PGE2 (10 mug/ml). It is inferred that the stimulatory effect of PGE2, on LH release is not a direct one on the pituitary gland, but is exerted at the level of the hypothalamus.
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