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  • Title: [Clinical features of HLA-B27 positive and negative uveitis].
    Author: Tarasova LN, Drozdova EA.
    Journal: Vestn Oftalmol; 2000; 116(3):25-7. PubMed ID: 10918847.
    Abstract:
    A total of 147 patients with uveitis concomitant with spondyloarthritis were examined. HLA-B27 histocompatibility antigen was detected in 75.5% patients. Men, mainly young and middle-aged, suffering from sacroileitis, developed the disease 2.5 times more often. Involvement of the uveal tract manifested by acute anterior fibrinous plastic uveitis (83.7%), rarely by anterior serous uveitis (16.3%). Bilateral uveitis occurred in 46.8% patients. HLA-B27-associated uveitis was characterized by a frequently relapsing course. On the other hand, fundus oculi abnormalities were detected in 12.6% patients with anterior uveitis; this abnormality occurs 4 times more often in subjects with negative HLA-B27 antigen, peripheral uveitis occurring 7 times more often. Complications were observed in 29.5% patients, their frequency and severity did not depend on the presence of HLA-B27 antigen.
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