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  • Title: Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats.
    Author: Bhanwra S, Singh J, Khosla P.
    Journal: Indian J Physiol Pharmacol; 2000 Jan; 44(1):64-8. PubMed ID: 10919097.
    Abstract:
    The effect of aqueous leaf extract of Azadirachta indica (A. indica) was evaluated in paracetamol induced hepatotoxicity in rats. Liver necrosis was produced by administering single dose of paracetamol (2 g/kg, p.o.). The liver damage was evidenced by elevated levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Aqueous A. indica leaf extract (500 mg/kg, p.o.) significantly (P < 0.01) reduced these elevated levels of AST, ALT and gamma-GT. Paracetamol induced liver necrosis was also found to be reduced as observed macroscopically and histologically.
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