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  • Title: An in vivo study of an antimicrobial mouth rinse on supragingival and subgingival plaque and calculus formation.
    Author: Rokita JR, Hazen SP, Millen D, Volpe AR.
    Journal: Pharmacol Ther Dent; 1975; 2(1):1-11. PubMed ID: 1091935.
    Abstract:
    An antibiotic mouth rinse (CC10232) was used twice a day for one week in human subjects in a supervised double blind clinical and histological study. Nylon strips were placed supra and subgingivally for one week and then sectioned, stained and examined. Results showed that the rinse containing CC-10232 reduced the amount of plaque and reduced the amount of mineralization in 4 of 5 subjects.Also, no spirochetes were found in subjects who utilized this rinse.
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