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  • Title: [Study on the status of methylation of Rb gene promoter in human esophageal cancer and effect of NMBzA on Rb gene promoter in monkey esophageal epithelium].
    Author: Li H, Lu S, Fong L.
    Journal: Zhonghua Zhong Liu Za Zhi; 1998 Nov; 20(6):412-4. PubMed ID: 10920930.
    Abstract:
    OBJECTIVE: To elucidate the cause of abnormal Rb expression in esophageal cancer (EC). METHODS: Methylation of Rb gene promoter was examined with restriction endonuclease digestion and PCR amplification. RESULTS: Of the 30 specimens of EC, 10 (33.3%) had Msp I type hypermethylation of the Rb gene promoter while 12 (40.0%) had Hpa II type hypermethylation and one had both type of hypermethylation. In monkey fed with a single dose of NMBzA (30 mg/kg) on day 0, increasing hypermethylation of both types of the Rb gene promoter in esophageal epithelium was found on day 1, 2 and 3 but reduced on day 5. CONCLUSION: These data suggest that abnoromal expression of Rb gene may be related to hypermethylation of its promoter and carcinogen NMBzA can induce such hypermethylation in monkey esophageal epithelium.
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