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  • Title: [Deletion of MTS1/p16 gene in human esophageal carcinoma].
    Author: Jin S, Peng Q, Lu S.
    Journal: Zhonghua Zhong Liu Za Zhi; 1998 Jan; 20(1):9-11. PubMed ID: 10921045.
    Abstract:
    OBJECTIVE: To investigate the alteration of MTS1/p16 gene in human esophageal carcinoma. METHODS: A total of 60 human esophageal tissue specimens, comprising 30 squamous-cell carcinomas and 30 tumor-adjacent tissue specimens, were examined for homozygous deletion of p16 gene by using Southern blot hybridization and PCR method. RESULTS: The results showed that no deletions were detected in 30 tumor-adjacent tissue samples. However, of 30 esophageal carcinoma specimens, 7 were found negative for p16 gene in Southern blot assay, and the deletion of the p16 gene in 5 samples were confirmed by PCR with a 16.7% p16 gene deletion rate. CONCLUSION: These data suggest that MTS1/p16 gene alterations may play a role in the progression of human esophageal carcinoma.
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