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  • Title: Pathological mechanisms to explain some cases of amenorrhoea without organic disease.
    Author: Shaw RW, Butt WR, London DR.
    Journal: Br J Obstet Gynaecol; 1975 Apr; 82(4):337-40. PubMed ID: 1092322.
    Abstract:
    A test is described to define the site of the lesion causing amenorrhoea in women of child-bearing age who have normal ovaries and a normal response to luteinizing hormone-releasing hormone (LH-RH). Patients able to produce a release of LH following the administration of 1 mg. of oestradiol benzoate (EB) have normal hypothalamic function and thus the site of the defect must lie more centrally in the brain. Patients unable to show these LH surges have either a primary or secondary abnormality affecting their hypothalamic oestrogen "receptor" mechanisms or their ability to produce LH-RH.
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