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  • Title: [Changes of plasma nitric oxide and endothelin levels in normal pregnant women and pregnancy induced hypertension].
    Author: Zhao Y, Zhang W, Wang L.
    Journal: Zhonghua Yi Xue Za Zhi; 1998 Jun; 78(6):457-9. PubMed ID: 10923512.
    Abstract:
    OBJECTIVE: To investigate the relationship of nitric oxide (NO), endothelin-1 (ET-1) levels and pregnancy induced hypertension (PIH). METHODS: 60 patients with PIH, 45 normal pregnant women and 15 normal non-pregnant women were studied. Plasma NO levels were determined. The stable metabolic product NO2-/NO3- of NO was letermined by Griess reaction. Plasms ET-1 levels were measured with radioimmunoassay. RESULTS: The NO2-/NO3- levels of the normal pregnancy group were significantly higher than those of the control group (P < 0.01), particularly in the second trimester of pregnancy. The NO2-/NO3- level of PIH was significantly lower in maternal plasma than that of the last trimester of normal pregnancy (P < 0.01) and nonpregnancy (P < 0.05), and it decreased with the disease development. In severe PIH the umbilical venous blood NO2-/NO3- level was significantly lower than that in the normal term pregnancy group (P < 0.01). The maternal plasma ET-1 level in PIH was significantly higher than that in the normal term pregnancy and control groups (P < 0.01). CONCLUSION: PIH might be related to decreasing synthesis and release of NO, and increasing ET-1 production.
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