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  • Title: Study on colloidal Au-enhanced DNA sensing by quartz crystal microbalance.
    Author: Lin L, Zhao H, Li J, Tang J, Duan M, Jiang L.
    Journal: Biochem Biophys Res Commun; 2000 Aug 11; 274(3):817-20. PubMed ID: 10924359.
    Abstract:
    Colloidal Au is reported for enhancement the immobilization capacity and ultimately detection limit of DNA using quartz crystal microbalance (QCM). Immobilization of approximately 12 nm-diameter colloidal Au on to an Au-coated QCM resulted in an easier attachment of oligonucleotide, with a mercaptohexyl group at the 5'-phosphate end and an increased capacity for nucleic acid detection. DNA immobilization and hybridization was monitored from QCM frequency changes. Hybridization was induced by exposure of the DNA-containing films to complementary DNA in solution. A much higher sensitivity was obtained for the analyte. The Au nanoparticle films on the Au plate provide a novel means for the fabrication of DNA sensor.
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