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  • Title: Mode of replication of plasmid lambda-dv-1.
    Author: Matsubara K, Mukai T.
    Journal: J Biochem; 1975 Feb; 77(2):373-82. PubMed ID: 1092674.
    Abstract:
    About 20 copies of plasmid lambda-dv are perpetuated per host chromosome in Escherichia coli K12 cells. The mode of DNA replication of this plasmid lambda-dv was studied, using the density-labelling technique followed by banding in DsCl. It was shown that all the copies of plasmid lambda-dv are potentially capable of replicating roughly once a cell generation. Their replication occurs by random, that is a copy of the plasmid is taken out at random for replication from a pool, to which the two replicas resulting from replication are returned. Chloramphenicol did not inhibit the initiation of a new round of replication of the plasmid molecules, indicating that selection from the replication pool does not require concomitant protein synthesis.
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