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  • Title: Pathogenesis of rabies in immunodeficient mice.
    Author: Kaplan MM, Wiktor TJ, Koprowski H.
    Journal: J Immunol; 1975 Jun; 114(6):1761-5. PubMed ID: 1092760.
    Abstract:
    The HEP and ts2 strains of rabies virus inoculated intracerebrally into adult mice normally cause clinically inapparent infection. In the experiments described, this is converted into a lethal infection by immunosuppression with cyclophosphamide, which also prevented induction of immunity with vaccine. Lethal infection of HEP-inoculated mice was also observed in mice treated with antihymocytic serum, and in athymic (BALB/c-nu) nude mice.
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