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  • Title: Effect of thiamine hydrochloride on lead induced lipid peroxidation in rat liver and kidney.
    Author: Senapati SK, Dey S, Dwivedi SK, Patra RC, Swarup D.
    Journal: Vet Hum Toxicol; 2000 Aug; 42(4):236-7. PubMed ID: 10928693.
    Abstract:
    Thiamine hydrochloride was studied on lead-induced endogenous lipid peroxidation in rat hepatic and renal tissues following po doses of 2.73 mg lead/kg bw for 6 w. Simultaneous use of 25 mg thiamine hydrochloride/kg bw po reduced lead accumulation in liver and kidneys. There were significant decreases in endogenous lipid peroxide in liver and kidney from thiamine hydrochloride-treated rats. Histopathological lesions in thiamine-treated livers and kidneys were milder in comparison to lesions in untreated Pb-exposed animals. This indicates the prophylactic potential of thiamine for lead-induced lipid peroxidation.
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