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  • Title: Mechanisms of growth cone guidance and motility in the developing grasshopper embryo.
    Author: Isbister CM, O'Connor TP.
    Journal: J Neurobiol; 2000 Aug; 44(2):271-80. PubMed ID: 10934328.
    Abstract:
    During neuronal pathfinding in vivo, growth cones must reorient their direction of migration in response to extracellular guidance cues. The developing grasshopper limb bud has proved to be a model system in which to examine mechanisms of growth cone guidance and motility in vivo. In this review we examine the contributions of adhesion and multiple guidance cues (semaphorins 1 and 2) in directing a growth cone steering event. Recent observations have suggested that the tibial pioneer growth cones are not directed via mechanisms of differential adhesivity. We present a model of growth cone steering that suggests a combination of adhesive and guidance receptors are important for a correct steering event and that guidance molecules may be important regulators of adhesive interactions with the actin cytoskeleton.
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