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  • Title: Characterization of substance P-membrane interaction by transferred nuclear Overhauser effect.
    Author: Augé S, Bersch B, Tropis M, Milon A.
    Journal: Biopolymers; 2000 Oct 15; 54(5):297-306. PubMed ID: 10935970.
    Abstract:
    Substance P, one of the mammalian tachykinins, is known to interact strongly with lipid bilayers and this interaction may play a role in the receptor-peptide recognition process. The conformation of substance P bound to vesicles consisting of perdeuterated phosphatidylcholine has been investigated by means of two-dimensional transferred nuclear Overhauser (trNOE) spectroscopy. Nuclear magnetic resonance data analysis resulted in a unique conformational family characterized by a well-defined conformation of the last seven C-terminal amino acids, which consists of a sequence of nonstandard turns following each other in a helix-like manner. The absence of short- or medium-range trNOE in the N-terminal part indicates its structural flexibility.
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