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  • Title: The master rep concept in nanovirus replication: identification of missing genome components and potential for natural genetic reassortment.
    Author: Timchenko T, Katul L, Sano Y, de Kouchkovsky F, Vetten HJ, Gronenborn B.
    Journal: Virology; 2000 Aug 15; 274(1):189-95. PubMed ID: 10936099.
    Abstract:
    Faba bean necrotic yellows virus (FBYNV), Milk vetch dwarf virus (MDV), and Subterranean clover stunt virus (SCSV) are nanoviruses that infect leguminous plants. From MDV- and SCSV-infected tissue we identified viral DNAs that encode a replication initiator protein (Rep), essential for replication of the multiple circular single-stranded DNAs of these viruses. These previously undescribed Rep proteins of MDV and SCSV are strikingly similar in sequence and functionally equivalent to the master Rep protein of FBYNV. Moreover, we demonstrated that the master Rep proteins of the three viruses are able to trigger replication of heterologous nanovirus DNAs. Such cross-species replication may reflect a considerable potential for genetic reassortment among nanoviruses in nature and be of significance for their evolution.
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