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  • Title: Comparison of trimethoprim-sulfamethoxazole with sulfamethoxazole in urinary tract infections of children.
    Author: Feldman W, Johnson DM, Newberry P, Weldon A, Naidoo S.
    Journal: Can Med Assoc J; 1975 Jun 14; 112(13 Spec No):19-21. PubMed ID: 1093648.
    Abstract:
    The effect of trimethorpim-sulfamethoxazole was compared with that of sulfamethoxazole alone in 26 children with urinary tract infection, randomly assigned according to a double-blind procedure to two equally sized groups. TMX-SMX was found to be superior in rendering the urine culture negative for the 3 months after the start of treatment. Also, over 12-month follow-up period there were fewer recurrences in the patients who received TMP-SMX but here the difference between the two groups did not reach statistical significance.
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