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  • Title: Frequency doubling perimetry in resolved optic neuritis.
    Author: Fujimoto N, Adachi-Usami E.
    Journal: Invest Ophthalmol Vis Sci; 2000 Aug; 41(9):2558-60. PubMed ID: 10937566.
    Abstract:
    PURPOSE: To study the visual field with frequency doubling technology (FDT) in patients with recovered optic neuritis and to detect loss of magnocellular projecting cells (M cells) in the extrafovea. METHODS: Fourteen patients who had undergone one attack of optic neuritis and recovered normal vision (1.0 or better) and critical fusion frequency were examined with conventional Humphrey automated perimetry central 30-2 and FDT c-20 threshold tests. After 1 year, 12 patients were reexamined with central 30-2 and FDT c-20 tests. The visual fields examined by both perimeters were divided into three zones. The mean sensitivity in each zone in involved eyes, uninvolved eyes, and involved eyes after 1 year was compared with that in healthy eyes. RESULTS: Conventional automated perimetry showed depression toward the fovea. However, FDT demonstrated general depression, especially midperipheral deficits. After 1 year, the midperipheral deficits with frequency doubling perimetry (FDP) improved, as did central depression, as observed with central 30-2 tests. CONCLUSIONS: FDT was developed to detect early glaucomatous damage, which was thought to be caused by a loss of M cells. Our study suggested that patients with resolved optic neuritis also had a loss of M-cell function in the extrafoveal area, as observed by field damage and its recovery.
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