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  • Title: Analysis of tnrA alleles which result in a glucose-resistant sporulation phenotype in Bacillus subtilis.
    Author: Shin BS, Choi SK, Smith I, Park SH.
    Journal: J Bacteriol; 2000 Sep; 182(17):5009-12. PubMed ID: 10940050.
    Abstract:
    Bacillus subtilis cells cannot sporulate in the presence of catabolites such as glucose. During the analysis of Tn10-generated mutants, we found that deletion of the C-terminal region of the tnrA gene, which encodes a global regulator that positively regulates a number of genes in response to nitrogen limitation, results in a catabolite-resistant sporulation phenotype. Analyses of nrg-lacZ and nasB-lacZ, which are activated by TnrA under nitrogen limitation, showed that C-terminally truncated TnrA activates nitrogen-regulated genes constitutively. The relief of catabolite repression of sporulation may result from the uncontrolled expression of the TnrA-regulated genes.
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