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  • Title: A beta fibrillogenesis: kinetic parameters for fibril formation from congo red binding.
    Author: Inouye H, Kirschner DA.
    Journal: J Struct Biol; 2000 Jun; 130(2-3):123-9. PubMed ID: 10940220.
    Abstract:
    Using Scatchard analysis, we have formulated as a function of time and pH the relationship between the binding of Congo red to Alzheimer's beta-amyloid and the aggregation number (i.e., monomer concentration within fibrils) as defined by nucleation-dependent self-assembly. This provides a basis on which to determine the kinetic parameters for fibril formation from the observed concentration of bound Congo red.
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