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  • Title: The effects of sarin-like and soman-like organophosphorus agents on MAPK and JNK in rat brains.
    Author: Niijima H, Nagao M, Nakajima M, Takatori T, Iwasa M, Maeno Y, Koyama H, Isobe I.
    Journal: Forensic Sci Int; 2000 Aug 14; 112(2-3):171-8. PubMed ID: 10940602.
    Abstract:
    One sarin-like and one soman-like organophosphorus agent [bis(isopropyl methyl)phosphonate, BIMP and bis(pinacolyl methyl)phosphonate, BPMP] were injected intravenously (iv) in rats. An increase in the tyrosine phosphorylation of several proteins in the cytosol fraction of the brain was observed. Activation of c-Jun N-terminal kinase (JNK) and slight activation of mitogen-activated protein kinase (MAPK) in the cytosol were also observed. The activation of these enzymes may be related to the high toxicity of these nerve agents.
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