These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Role of the outer membrane in the accumulation of quinolones by Serratia marcescens.
    Author: Berlanga M, Ruiz N, Hernandez-Borrell J, Montero T, Viñas M.
    Journal: Can J Microbiol; 2000 Aug; 46(8):716-22. PubMed ID: 10941517.
    Abstract:
    Accumulation of four quinolones by Serratia marcescens was measured fluorometrically. The passage of quinolones through the outer membrane was studied in both lipopolysaccharide-deficient and porin-deficient mutants. The lipopolysaccharide (LPS) layer formed a partially effective barrier for highly hydrophobic quinolones such as nalidixic acid. Quinolones with a low relative hydrophobicity coefficient seemed to pass preferentially through the water-filled Omp3 porin channels. Results were confirmed when Omp3 was cloned in a porin-defective Escherichia coli.
    [Abstract] [Full Text] [Related] [New Search]