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  • Title: Changes in paraoxonase and apolipoprotein A-I, B, C-III and E in subjects with combined familiar hyperlipoproteinemia treated with ciprofibrate.
    Author: Turay J, Grniaková V, Valka J.
    Journal: Drugs Exp Clin Res; 2000; 26(3):83-8. PubMed ID: 10941600.
    Abstract:
    The aim of our study was to determine whether, in patients with familiar combined hyperlipoproteinemia (FCH), ciprofibrate produces changes in paraoxonase, which acts as an antioxidant. A further aim was to estimate changes in serum levels of apolipoproteins, especially in apolipoprotein (apo) A-I and apoC-III. One of the mechanisms of action of fibrates is the activation apo A-I biosynthesis and the inhibition of apoC-III production. It is performed in the liver through peroxisome proliferator activated receptor (PPAR)-alpha activity. We found that ciprofibrate administration enhanced production of apoA-I and paraoxonase transport capacity. Decreases in paraoxonase during ciprofibrate treatment were not statistically significant but increases in serum levels of apoA-I were statistically significant. Levels of apoC-III were decreased, which suggests that ciprofibrate belongs in the group of fibrates that influences lipoprotein metabolism through PPAR-alpha activity.
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