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  • Title: Association of t(9;11)-MLL AF9 and trisomy 8 in an AML-M5 preceded by pancytopenia.
    Author: Anguita E, Barrio CG, González FA, Ferro MT, del Potro E, Ropero P, Villegas A.
    Journal: Cancer Genet Cytogenet; 2000 Jul 15; 120(2):144-7. PubMed ID: 10942806.
    Abstract:
    The implication of MLL gene rearrangements in the prognosis of acute myeloblastic leukemia is an issue of considerable current interest. We report a case of a young man who initially presented with a pancytopenia and went on to develop a highly-aggressive acute myeloblastic leukemia. At this time, the karyotypic study revealed trisomy 8, a t(9;11) was demonstrated by fluorescence in situ hybridization (FISH) and the MLL/AF4 rearrangement by reverse transcriptase-polymerase chain reaction (RT-PCR).
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