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  • Title: [Effectiveness of dietary non-starch polysaccharides in experimental toxic hepatitis].
    Author: Khotimchenko IuS, Khasina EI, Kovalev VV, Shevtsova OI, Shestakova SV.
    Journal: Vopr Pitan; 2000; 69(1-2):22-6. PubMed ID: 10943000.
    Abstract:
    The efficiency of some polysaccharides was investigated in mice with an experimental toxic hepatitis. Hepatitis was induced by the oral administration of 10% solution CCl4 in olive oil at a dosage of 3 ml/kg body weight every day during 7 days. After that tested substances were administrated every day 30-40 min before a feeding at a dosage of 150 mg/kg body weight during 14-21 days. Results showed that a calcium alginate, two low-methoxyl pectins (one with the degree of esterification about 50% and other with the degree of esterification less 5%), fucoidan, and chitozan, but not lambda-carrageenan and kappa-carrageenan, have beneficial affects on liver total lipid, glycogen, malondialdehyde, and diene conjugates as well as on blood total lipid and alanine aminotransferase activity in animals with experimental toxic hepatitis.
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