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  • Title: [Bone marrow granulomatosis in Q-fever].
    Author: Rexroth G, Rösch W, Altmannsberger M.
    Journal: Med Klin (Munich); 2000 Jul 15; 95(7):404-8. PubMed ID: 10943102.
    Abstract:
    BACKGROUND: Petersdorf and Beeson defined Fever of Unknown Origin (FUO) as an illness characterized by rectal temperature exceeding 38.3 degrees C on at least 3 occasions, evolving during at least 3 weeks, with no diagnosis reached after 1 week of in-patient investigation. A quarter of FUO cases is caused by infectious diseases, most often hidden abscesses, subacute endocarditis and tuberculosis. CASE REPORT: In a 29-year-old patient with undulating fever of 3 months duration solely the demonstration of bone marrow fibrin ring granulomas led to the diagnosis of protracted Q-fever. The diagnosis later has been proved by elevated Coxiella burnetii antibody titers. CONCLUSION: The case report underlines the diagnostic value of bone marrow biopsy in the evaluation of fever of unknown origin.
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