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  • Title: The major histocompatibility complex-encoded HFE in iron homeostasis and immune function.
    Author: Salter-Cid L, Peterson PA, Yang Y.
    Journal: Immunol Res; 2000; 22(1):43-59. PubMed ID: 10945226.
    Abstract:
    HFE is a non-classical major histocompatibility complex class I molecule that complexes with a beta2-microglobulin. A functional link between HFE and iron metabolism has been established by the discovery of a physical association between HFE and the transferrin receptor. By inhibiting transferrin receptor internalization, HFE functions as a negative modulator of transferrin receptor function. In addition, HFE appears to be an iron sensor that directly or indirectly communicates the body's iron status to T cells, which then use cytokines as feedback modulators to achieve iron homeostasis. A working model for the feedback regulatory mechanism between iron metabolism and immune function is proposed.
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