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  • Title: Amplification of the cyclin A gene in canine and feline mammary tumors.
    Author: Murakami Y, Tateyama S, Rungsipipat A, Uchida K, Yamaguchi R.
    Journal: J Vet Med Sci; 2000 Jul; 62(7):783-7. PubMed ID: 10945302.
    Abstract:
    DNAs from 33 canine mammary tumors and 8 feline mammary carcinomas were examined by Southern blot analysis to clarify genomic abnormalities of the cyclin A gene. Amplification of cyclin A was detected in 27.3% (9/33) of canine mammary tumors and 87.5% (7/8) of feline mammary carcinomas. It was suggested that amplification of cyclin A do not correlate directly with the tumorigenesis of canine mammary tumors, because there was no significant difference of incidence of cyclin A amplification between the benign and malignant tumors. In feline mammary carcinomas, the high frequency of cyclin A amplification raised the possibility that the amplification lead to the protein overexpression and play an important role in the tumorigenesis.
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