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  • Title: Mapping of a gene for nonspecific X-linked mental retardation (MRX 75) to Xq24-q26.
    Author: Caspari R, Uhlhaas S, Friedl W, Knapp M, Propping P.
    Journal: Am J Med Genet; 2000 Aug 14; 93(4):290-3. PubMed ID: 10946355.
    Abstract:
    Nonspecific X-linked mental retardation is a heterogeneous condition consisting of nonsyndromal mental retardation in males. It is caused by mutation in one of several genes on the X chromosome (MRX genes). Here we report on the localization of a presumptive MRX gene to chromosomal region Xq24-q26 in a German family with nonspecific X-linked mental retardation (MRX 75, HUGO Human Gene Nomenclature Committee). Two point linkage analysis with 23 informative markers gave a lod score of 2.53 at theta = 0 for markers DXS425, DXS1254, DXS1114, and HPRT.
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