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  • Title: Cellular sites of immunoglobulins . VI. Localization of immunoglobulins in the human thymus.
    Author: Chen ST, Tobe T, Iosobe Y, Chiu AF.
    Journal: Acta Pathol Jpn; 1975 Jan; 25(1):69-73. PubMed ID: 1094798.
    Abstract:
    IgG-, IgM and IgA-containing cells in the human thymus and mesenteric lymph nodes were studied by direct, double-antibody immunofluorescence techniques. Ig-containing cells were identified in the thymic medulla but not in cortical or paracortical zones. About 93 percent of the medullary Ig-containing cells were IgG-containing (vs. 5 percent IgM containing and 2 percent IgA - containing). By contrast, lymph nodes contained about 53 percent IgG, 31 percent IgA and 16 percent IgM type immunocytes. In addition, Ig-containing cells were about one-tenth as numerous in thymus as in lymph nodes.
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