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  • Title: Five exon 1 variants of mu opioid receptor and vulnerability to alcohol dependence.
    Author: Gscheidel N, Sander T, Wendel B, Heere P, Schmidt LG, Rommelspacher H, Hoehe MR, Samochowiec J.
    Journal: Pol J Pharmacol; 2000; 52(1):27-31. PubMed ID: 10949117.
    Abstract:
    The human mu opioid receptor (hMOR) gene is a prime candidate gene responsible for addictive disorders. The present association study tested the hypothesis that hMOR exon 1 variants elicit susceptibility to alcohol dependence. We have analyzed five nucleotide changes in exon 1 of the hMOR gene. Three of them are in the 5'untranslated region of exon 1 at positions -172G/T,-111C/T and -3 8C/A, the remaining two variants cause amino acid substitutions: +17C/T (Ala6Val) and +118A/G (Asn40Asp). Our population-based association study included 327 German alcohol-dependent subjects and 340 ethnically matched controls. The lack of an allelic association suggests that the analyzed hMOR exon 1 variants do not contribute a common and substantial effect to the genetically determined vulnerability of alcohol dependence.
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