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  • Title: [Neuronal dysplasia of the colon. A case report].
    Author: Mistrangelo M, Linari A, Capuzzi P, Labriola D, Serra GC, Bertotti E, Zorzi D, Corno F.
    Journal: Minerva Chir; 2000 May; 55(5):363-6. PubMed ID: 10953574.
    Abstract:
    A clinical case of Neuronal Intestinal Dysplasia (NID) is reported. This is an important pathology which is part of congenital alterations of bowel's innervation. This disease consists of two forms (A and B) which occur during different ages causing problems in intestinal motility with consequent various symptoms. Actually NID is diagnosed easier than in the past because histopathological techniques are very refined and permit to distinguish NID from cases once classified as Hirschsprung's disease. Histology can show an increase of Ach and Ldh activity in cholinergic fibers of lamina propria and of circular layer of intestinal wall. In this report a chronic status of constipation refractory to medical therapy has been treated with a total colectomy and an ileo-rectal anastomosis, resulting in a complete resolution of symptoms.
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