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  • Title: [Apoptosis in allergic disease].
    Author: Rojas Ramos E, Martínez Jiménez NE, Martínez Aguilar NE, Garfias Becerra J.
    Journal: Rev Alerg Mex; 2000; 47(4):134-7. PubMed ID: 10957879.
    Abstract:
    Apoptosis (cell programmed death) it is a mechanism that implicate a physiological suicide, to keep the cellular homeostasis in big amount of tissues. Fas (APO-1; CD95) system is one of the most important cellular responsible via to induce apoptosis on different tissues. Eosinophillia on peripheral blood and tissues are the main characteristics on allergic like asthma. Eosinophil apoptosis is upper regulated in those diseases by IL-5 y GM-CSF. Corticoids, teophyllin and some macrolids have been used like apoptosis inductors on eosinophills, these could be a novel mechanism to promote a better solution on inflammatory allergic diseases.
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