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  • Title: Wnt/beta-catenin signaling.
    Author: Akiyama T.
    Journal: Cytokine Growth Factor Rev; 2000 Dec; 11(4):273-82. PubMed ID: 10959075.
    Abstract:
    The Wnt/Wingless signaling transduction pathway plays an important role in both embryonic development and tumorigenesis. beta-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes. Recent studies have revealed that a number of proteins such as, the tumor suppressor APC and Axin are involved in the regulation of the Wnt signaling pathway. Furthermore, mutations in APC or beta-catenin have been found to be responsible for the genesis of human cancers.
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