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  • Title: Stimulation and recording from regenerated peripheral nerves through polyimide sieve electrodes.
    Author: Navarro X, Calvet S, Rodríguez FJ, Stieglitz T, Blau C, Butí M, Valderrama E, Meyer JU.
    Journal: J Peripher Nerv Syst; 1998; 3(2):91-101. PubMed ID: 10959242.
    Abstract:
    This paper describes the use of a new polyimide sieve electrode as a chronic neural interface to stimulate and record signals from regenerated peripheral nerves. Flexible thin polyimide electrodes were placed in silicone chambers and implanted between the severed ends of the sciatic nerve in rats. The sieve part of the interface has 281 round via holes of 40 microns diameter, with seven integrated recording-stimulating electrodes arranged around via holes. Axonal regeneration through the via holes was demonstrated by histological and physiological methods over a two to six month post-implantation period in all the rats. The regenerated nerves were organized in fascicles corresponding to the grid pattern of the via holes. Longitudinal sections showed myelinated fibers, with normal appearance and well developed myelin sheath, crossing the via holes. Stimulation of the regenerated nerve through the polyimide electrode evoked distal muscle and nerve responses similar in amplitude to those evoked by nerve stimulation with hook metal electrodes. The polyimide electrodes were useful for recording nerve action potentials in response to electrical stimulation of the distal regenerated nerve, and in response to functional sensory stimulation of several modalities.
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