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  • Title: Interaction of carbamazepine and phenobarbital in rabbits.
    Author: Rukhadze MD, Alexishvili MM, Okujava NV, Sebiskveradze MV, Okujava VM, Tsagareli SK.
    Journal: Biomed Chromatogr; 2000 Aug; 14(5):344-8. PubMed ID: 10960836.
    Abstract:
    The interaction of carbamazepine and phenobarbital in rabbits was investigated. The drugs were administered to the rabbit orally as a single dose. By simultaneous administration the sequence of drugs was varied, with an interval between doses of 15 min. The doses of carbamazepine and phenobarbital were 100 and 25 mg, respectively. It was established that phenobarbital appears to be an inductor for carbamazepine independently sequence of administration of the drugs. Carbamazepine reveals inductive properties for phenobarbital in the case where phenobarbital enteres in the organism first. It was ascertained also that, by simultaneous administration, these drugs reduce absorption of each other in plasma.
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