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  • Title: Amination of aromatic olefins with anilines: a new domino synthesis of quinolines.
    Author: Beller M, Thiel OR, Trauthwein H, Hartung CG.
    Journal: Chemistry; 2000 Jul 14; 6(14):2513-22. PubMed ID: 10961395.
    Abstract:
    A new catalytic amination of aromatic olefins with anilines is presented. In a domino reaction, substituted quinoline derivatives are obtained in the presence of cationic rhodium complexes, such as [Rh(cod)2]BF4, and PPh3. Ethylbenzene is formed as a by-product in this new oxidative reaction. The first transition metal catalyzed anti-Markovnikov hydroamination of styrene with anilines occurs as a side reaction. Mechanistic investigations strongly support the regioselective oxidative amination of styrene as the key reaction step.
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